SCHEMBL9503759

SCHEMBL9503759

CCc1ccc(C(=O)Cl)cc1[N+](=O)[O-]

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 2/20 0.70
ALDH1A1 P00352 4/20 0.49
TSHR P16473 2/20 0.47
VCAM1 P19320 1/20 0.47
HCAR3 P49019 7/20 0.47
CASP6 P55212 1/20 0.46
CYP1A2 P05177 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
HSP90AA1 P07900 1/20 0.43
HPGD P15428 1/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11749054 0.90 PDK1 (0.58) PDK1ALDH1A1TSHRVCAM1HCAR3
SCHEMBL1609387 0.87 PDK1 (0.54) PDK1ALDH1A1TSHRVCAM1HCAR3
SCHEMBL11748103 0.86 PDK1 (0.55) PDK1ALDH1A1TSHRVCAM1HCAR3
SCHEMBL28269442 0.85 PDK1 (0.52) PDK1ALDH1A1TSHRVCAM1HCAR3
SCHEMBL27639792 0.85 PDK1 (0.52) PDK1ALDH1A1TSHRVCAM1HCAR3
SCHEMBL20757 0.85 PDK1 (0.68) PDK1TSHRHCAR3CASP6KMT2A
SCHEMBL4173251 0.85 PDK1 (0.68) PDK1ALDH1A1TSHRHCAR3CASP6
SCHEMBL1091563 0.83 PDK1 (0.66) PDK1ALDH1A1TSHRHCAR3KMT2A
SCHEMBL16959624 0.83 PDK1 (0.65) PDK1ALDH1A1TSHRVCAM1HCAR3
SCHEMBL5913206 0.81 PDK1 (0.62) PDK1ALDH1A1TSHRHCAR3CASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543865-A1 BENZAMIDE DERIVATIVES RHONE-POULENC RORER LIMITED (GB) 1993-06-02 EP disclosed
WO-1992003412-A2 BENZAMIDE DERIVATIVES RHONE-POULENC RORER LIMITED (GB) 1992-03-05 WO disclosed
US-4052444-A DIAZO COUPLERS FOR MONOAZO DYES HOECHST AKTIENGESELLSCHAFT (DT) 1977-10-04 US disclosed