Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 3/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392767 | 0.87 | POLB (0.69) | POLBALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL21620954 | 0.87 | ALDH1A1 (0.61) | PTGS1AKR1C3AKR1C2ALDH1A1GAA | |
| SCHEMBL11462176 | 0.86 | PTGS1 (0.53) | PTGS1AKR1C3AKR1C2POLBALDH1A1 | |
| SCHEMBL1448732 | 0.85 | PTGS1 (0.73) | PTGS1AKR1C3AKR1C2POLBALDH1A1 | |
| Methane SCHEMBL9087821 | 0.84 | PTGS1 (0.71) | PTGS1AKR1C3AKR1C2POLBALDH1A1 | |
| SCHEMBL2168673 | 0.84 | PTGS1 (0.71) | PTGS1AKR1C3AKR1C2POLBALDH1A1 | |
| SCHEMBL11460900 | 0.83 | PTGS1 (0.69) | PTGS1AKR1C3AKR1C2POLBALDH1A1 | |
| SCHEMBL9584950 | 0.81 | AKR1C3 (0.54) | PTGS1AKR1C3AKR1C2POLBALDH1A1 | |
| SCHEMBL2662328 | 0.80 | MEN1 (0.57) | PTGS1AKR1C3AKR1C2ALDH1A1GAA | |
| SCHEMBL21451484 | 0.80 | CYP11B1 (0.59) | PTGS1AKR1C3AKR1C2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250693-A | Lipoxygenase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0547148-A1 | NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-23 | — | — | EP | disclosed |
| US-5208344-A | Benzothiazole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |
| WO-1992004325-A1 | NAPHTHALENEPROPIONIC ACID DERIVATIVES AS ANTI-INFLAMMATORY/ANTIALLERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5084575-A | Drugs for the treatment of rhinitis, asthma and skin disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |