SCHEMBL9504268

SCHEMBL9504268

CCOC(=O)C1=C(C(=O)OCC)C(c2cccc(Cl)c2)C(C(=O)OCC)=C(CCl)N1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 3/20 0.50
CACNA1D Q01668 3/20 0.50
CACNA1S Q13698 3/20 0.50
CACNA1C Q13936 3/20 0.50
CACNA1B Q00975 10/20 0.48
ABCC1 P33527 1/20 0.48
ADORA3 P0DMS8 2/20 0.47
ACHE P22303 1/20 0.44
MAPK1 P28482 1/20 0.44
MEN1 O00255 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.43
HIF1A Q16665 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11773488 0.91 CACNA1F (0.56) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL9513394 0.90 ABCC1 (0.58) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL11771568 0.87 ABCC1 (0.61) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL9519468 0.85 CACNA1F (0.47) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL9502395 0.84 CACNA1B (0.46) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
Hydrochloric Acid SCHEMBL9521725 0.84 CACNA1F (0.44) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL3026966 0.82 ABCC1 (0.71) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL11522715 0.81 ABCC1 (0.58) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL9675983 0.80 ABCC1 (0.57) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B
SCHEMBL11459111 0.78 ABCC1 (0.55) CACNA1FCACNA1DCACNA1SCACNA1CCACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458823-B1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1993-10-13 EP disclosed
US-5245039-A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA (IT) 1993-09-14 US disclosed
EP-0458823-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES. BOEHRINGER MANNHEIM ITALIA (IT) 1991-12-04 EP disclosed
WO-1990009376-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-23 WO disclosed
EP-0383320-A1 A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-22 EP disclosed