Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.54 |
| ▸ | DRD3 | P35462 | 7/20 | 0.54 |
| ▸ | DRD1 | P21728 | 5/20 | 0.54 |
| ▸ | DRD4 | P21917 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9507124 | 0.99 | DRD2 (0.55) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL22694038 | 0.90 | DRD2 (0.62) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL9507115 | 0.86 | DRD2 (0.70) | DRD2DRD3DRD1DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL9504453 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD1DRD4HTR1A | |
| SCHEMBL9506505 | 0.84 | DRD2 (0.43) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL9504552 | 0.81 | DRD2 (0.61) | DRD2DRD3DRD1DRD4HTR1A | |
| SCHEMBL9507046 | 0.79 | DRD2 (0.55) | DRD2DRD3DRD1DRD4HTR1A | |
| SCHEMBL22703437 | 0.79 | DRD3 (0.62) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL22694040 | 0.79 | DRD3 (0.62) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL9505378 | 0.79 | DRD3 (0.44) | DRD2DRD3DRD1DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |