Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 4/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506694 | 0.91 | PNP (0.70) | PNPHDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL9504559 | 0.88 | HDAC6 (0.62) | PNPHDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL9502951 | 0.86 | PNP (0.69) | PNPHDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL9506808 | 0.82 | PNP (1.00) | PNP | |
| SCHEMBL30759944 | 0.81 | FGFR1 (0.63) | PNPHDAC6HDAC1HDAC4HSP90AA1 | |
| SCHEMBL1566036 | 0.81 | FGFR1 (0.63) | PNPHDAC6HDAC1HDAC4HSP90AA1 | |
| SCHEMBL9502893 | 0.81 | PNP (0.69) | PNPHDAC6HDAC1HDAC4HDAC2 | |
| SCHEMBL12857150 | 0.80 | HDAC6 (0.70) | HDAC6HDAC1HDAC4HDAC2HSP90AA1 | |
| SCHEMBL21977307 | 0.79 | HDAC6 (0.69) | HDAC6HDAC1HDAC4HDAC2HSP90AA1 | |
| SCHEMBL25547980 | 0.79 | HDAC6 (0.69) | HDAC6HDAC1HDAC4HDAC2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550574-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005180-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | disclosed |