Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10768147 | 0.88 | METAP1 (0.44) | METAP1CYP1A2SIGMAR1METAP2HPGD | |
| SCHEMBL7334866 | 0.80 | METAP1 (0.50) | METAP1CYP1A2SIGMAR1METAP2 | |
| SCHEMBL10582459 | 0.80 | METAP1 (0.50) | METAP1CYP1A2SIGMAR1METAP2 | |
| SCHEMBL11741993 | 0.79 | METAP1 (0.44) | METAP1CYP1A2SIGMAR1METAP2HPGD | |
| SCHEMBL10769102 | 0.78 | METAP1 (0.41) | METAP1CYP1A2SIGMAR1METAP2 | |
| SCHEMBL1111381 | 0.77 | METAP1 (0.46) | METAP1LMNACYP1A2SIGMAR1METAP2 | |
| SCHEMBL10590223 | 0.74 | METAP1 (0.38) | METAP1CYP1A2SIGMAR1METAP2 | |
| SCHEMBL11739573 | 0.74 | METAP1 (0.42) | METAP1LMNACYP1A2SIGMAR1METAP2 | |
| SCHEMBL10771183 | 0.73 | METAP1 (0.43) | METAP1CYP1A2SIGMAR1METAP2HPGD | |
| SCHEMBL10791471 | 0.73 | CYP1A2 (0.50) | METAP1LMNACYP1A2SIGMAR1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546115-A1 | PEPTIDES CONTAINING AMINO-POLYOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |