Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.50 |
| ▸ | HMGCR | P04035 | 3/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL28268122 | 1.00 | LMNA (0.58) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL454017 | 1.00 | — | — | |
| SCHEMBL504189 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL9352237 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| Ammonia Solution, Strong SCHEMBL5709321 | 0.97 | LMNA (0.55) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL9351053 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL2210214 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL609292 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL3761638 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 | |
| SCHEMBL4188688 | 0.97 | TSHR (0.60) | LMNACYP2D6CYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373579-B1 | MANUFACTURE OF 5-CYANOVALERIC ACID AND ITS ESTERS USING CYCLIC COSOLVENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0373579-A1 | Manufacture of 5-cyanovaleric acid and its esters using cyclic cosolvents | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-06-20 | — | — | EP | disclosed |