Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.65 |
| ▸ | PLK1 | P53350 | 1/20 | 0.65 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.62 |
| ▸ | THRA | P10827 | 5/20 | 0.61 |
| ▸ | THRB | P10828 | 5/20 | 0.61 |
| ▸ | RARB | P10826 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | RARA | P10276 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060359 | 0.98 | HDAC1 (0.70) | HDAC1HDAC8PLK1SMPD1THRA | |
| Acetic Acid SCHEMBL9504786 | 0.95 | HDAC1 (0.71) | HDAC1HDAC8PLK1SMPD1THRA | |
| Acetic Acid SCHEMBL9504741 | 0.95 | HDAC1 (0.71) | HDAC1HDAC8PLK1SMPD1THRA | |
| SCHEMBL4185605 | 0.95 | RARB (0.69) | HDAC1HDAC8PLK1SMPD1THRA | |
| SCHEMBL6919330 | 0.93 | PLK1 (0.74) | HDAC1HDAC8PLK1THRATHRB | |
| SCHEMBL21628684 | 0.91 | HDAC1 (0.61) | HDAC1HDAC8PLK1SMPD1THRA | |
| SCHEMBL21628550 | 0.89 | HDAC1 (0.59) | HDAC1HDAC8PLK1SMPD1THRB | |
| SCHEMBL4824490 | 0.86 | PLK1 (0.65) | PLK1THRATHRBRARBMEN1 | |
| SCHEMBL9164847 | 0.86 | PLK1 (0.65) | PLK1THRATHRBRARBMEN1 | |
| SCHEMBL9206725 | 0.86 | PLK1 (0.65) | PLK1THRATHRBRARBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| CN-1012500-B | Process for preparing aryl hydroxamates | SQUIBB & SONS INC (US) | 1991-05-01 | — | — | CN | disclosed |
| CN-85104470-A | The method for preparing arythydroxamtes | — | 1986-10-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |