Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287722 | 0.80 | HAO1 (0.51) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL21628738 | 0.80 | ALDH1A1 (0.65) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL21628651 | 0.80 | ALDH1A1 (0.65) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL6822733 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL14231550 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL6822864 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL15081033 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL12337677 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL13445251 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 | |
| SCHEMBL28595922 | 0.78 | HDAC8 (0.59) | HDAC8HDAC6HDAC1HAO1DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| CN-85104470-A | The method for preparing arythydroxamtes | — | 1986-10-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |