⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946240 | 0.72 | — | — | |
| SCHEMBL6421859 | 0.67 | — | — | |
| SCHEMBL8088339 | 0.67 | — | — | |
| SCHEMBL6021901 | 0.67 | — | — | |
| SCHEMBL628489 | 0.64 | — | — | |
| SCHEMBL87811 | 0.61 | — | — | |
| SCHEMBL1155372 | 0.61 | — | — | |
| SCHEMBL5956027 | 0.57 | — | — | |
| SCHEMBL10401990 | 0.56 | — | — | |
| SCHEMBL16215556 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108659090-A | A kind of preparation method of 17 β-thiocarboxylic acids chloromethane esters steroidal compounds | 天津药业研究院有限公司 | 2018-10-16 | — | — | CN | claimed |
| CN-110343143-B | Preparation method of fluticasone propionate | 天津药业研究院股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| US-10604544-B2 | Methods for preparation of bile acids and derivatives thereof | INTERCEPT PHARMACEUTICALS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| CN-110343143-A | A kind of preparation method of fluticasone propionate | 天津药业研究院有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-108659090-A | A kind of preparation method of 17 β-thiocarboxylic acids chloromethane esters steroidal compounds | 天津药业研究院有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-108659090-A | A kind of preparation method of 17 β-thiocarboxylic acids chloromethane esters steroidal compounds | 天津药业研究院有限公司 | 2018-10-16 | — | — | CN | disclosed |
| US-20180222937-A1 | METHODS FOR PREPARATION OF BILE ACIDS AND DERIVATIVES THEREOF | INTERCEPT PHARMACEUTICALS, INC. | 2018-08-09 | — | — | US | disclosed |
| EP-3331896-A1 | METHODS FOR PREPARATION OF BILE ACIDS AND DERIVATIVES THEREOF | Intercept Pharmaceuticals, Inc. (US) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017027396-A1 | METHODS FOR PREPARATION OF BILE ACIDS AND DERIVATIVES THEREOF | INTERCEPT PHARMACEUTICALS, INC. (US) | 2017-02-16 | — | — | WO | disclosed |
| EP-0375559-B1 | STEROIDS CONTAINING AN ALKYTHIO RADICAL AT POSITION 4, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-07-21 | — | — | EP | disclosed |
| US-4988684-A | Steroids for the inhibition of aromatase for the treatment of cancer | ROUSSEL UCLAF (FR) | 1991-01-29 | — | — | US | disclosed |
| EP-0375559-A1 | Steroids containing an alkythio radical at position 4, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1990-06-27 | — | — | EP | disclosed |