SCHEMBL9505372

SCHEMBL9505372

C=CCOC(=O)C1=C(C)NC(CCl)=C(C(=O)OC)C1c1cccc2nonc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 5/20 0.61
CYP3A4 P08684 5/20 0.61
CYP1A2 P05177 4/20 0.61
CYP2C19 P33261 4/20 0.61
MEN1 O00255 4/20 0.61
KMT2A Q03164 4/20 0.61
TBXA2R P21731 4/20 0.61
SLC6A3 Q01959 4/20 0.61
ABCB11 O95342 4/20 0.61
CACNA1C Q13936 3/20 0.61
ADORA3 P0DMS8 3/20 0.61
OPRK1 P41145 3/20 0.61
SCN5A Q14524 3/20 0.61
KCNH2 Q12809 3/20 0.61
NR1I2 O75469 3/20 0.61
NR3C1 P04150 2/20 0.61
CYP2D6 P10635 2/20 0.61
PDE4D Q08499 2/20 0.61
NPSR1 Q6W5P4 2/20 0.61
OPRD1 P41143 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9502937 0.91 CYP2C9 (0.65) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL9829134 0.87 CYP2C9 (0.56) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL9501234 0.87 CYP2C9 (0.82) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
Hydrochloric Acid SCHEMBL9504304 0.86 CYP2C9 (0.56) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL10914974 0.82 CYP2C9 (0.71) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL7343428 0.82 CYP2C9 (0.77) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL10629630 0.82 CYP2C9 (0.70) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL4801736 0.81 CYP2C9 (0.85) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL10575266 0.80 CYP2C9 (0.68) CYP2C9CYP3A4CYP1A2CYP2C19MEN1
SCHEMBL7341259 0.80 CYP2C9 (0.73) CYP2C9CYP3A4CYP1A2CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458823-B1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1993-10-13 EP disclosed
US-5245039-A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA (IT) 1993-09-14 US disclosed
WO-1990009376-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-23 WO disclosed
EP-0383320-A1 A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-22 EP disclosed