Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905868 | 0.95 | KMT2A (0.62) | KMT2AMEN1RAB9AGAACYP3A4 | |
| Acetic Acid SCHEMBL27905064 | 0.94 | KMT2A (0.58) | KMT2AMEN1RAB9AGAACYP3A4 | |
| Hydrochloric Acid SCHEMBL15527205 | 0.93 | KMT2A (0.60) | KMT2AMEN1RAB9AGAACYP3A4 | |
| Nitric Acid SCHEMBL21799325 | 0.92 | KMT2A (0.58) | KMT2AMEN1RAB9AGAACYP3A4 | |
| SCHEMBL30388225 | 0.84 | KMT2A (0.71) | KMT2AMEN1RAB9AGAACYP3A4 | |
| SCHEMBL1745798 | 0.84 | KMT2A (0.71) | KMT2AMEN1RAB9AGAACYP3A4 | |
| SCHEMBL11582018 | 0.81 | KMT2A (0.58) | KMT2AMEN1RAB9AGAACYP3A4 | |
| SCHEMBL113558 | 0.81 | MEN1 (0.71) | KMT2AMEN1RAB9AGAACYP3A4 | |
| SCHEMBL6377318 | 0.81 | KMT2A (0.71) | KMT2AMEN1RAB9AGAACYP3A4 | |
| SCHEMBL175272 | 0.81 | MEN1 (0.71) | KMT2AMEN1RAB9AGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264348-B1 | Ureas | CIBA GEIGY AG (CH) | 1993-12-15 | — | — | EP | disclosed |
| EP-0337946-B1 | UREAS | CIBA-GEIGY AG (CH) | 1993-07-28 | — | — | EP | disclosed |
| US-4999046-A | Herbicides and plant growth regulators, agricultural use | CIBA-GEIGY CORPORATION (US) | 1991-03-12 | — | — | US | disclosed |
| US-4904778-A | Pyrimidine-2-phenylamino derivatives | CIBA-GEIGY CORP. (US) | 1990-02-27 | — | — | US | disclosed |
| EP-0337946-A1 | Ureas | CIBA-GEIGY AG (CH) | 1989-10-18 | — | — | EP | disclosed |
| US-4802909-A | PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0264348-A2 | Ureas | CIBA-GEIGY AG (CH) | 1988-04-20 | — | — | EP | disclosed |