Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.52 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | DRD1 | P21728 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10583058 | 0.90 | LMNA (0.52) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL9505201 | 0.90 | ITGB2 (0.52) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| SCHEMBL9506817 | 0.86 | CACNA1S (0.53) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| SCHEMBL10579347 | 0.85 | CACNA1S (0.52) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| SCHEMBL9505883 | 0.85 | CACNA1S (0.54) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL9506837 | 0.84 | ITGB2 (0.48) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL9505001 | 0.84 | CYP3A4 (0.61) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL9506781 | 0.82 | ITGB2 (0.46) | CYP1A2CYP2D6LMNACYP3A4KCNH2 | |
| SCHEMBL9503765 | 0.80 | CACNA1S (0.60) | LMNACYP3A4KCNH2ADRA1AABCB11 | |
| SCHEMBL9505980 | 0.79 | CACNA1S (0.60) | CYP1A2CYP2D6LMNACYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279425-B1 | USE OF BENZOTHIAZEPINE DERIVATIVES, IN PARTICULAR DILTIAZEM, IN THE MANUFACTURE OF MEDICAMENTS TO PROTECT LYMPHOCYTES | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1993-08-04 | — | — | EP | disclosed |
| US-4861770-A | Use of benzothiazepine derivatives as lymphocyte protectors | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1989-08-29 | — | — | US | disclosed |
| EP-0279425-A2 | Use of benzothiazepine derivatives, in particular diltiazem, in the manufacture of medicaments to protect lymphocytes | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1988-08-24 | — | — | EP | disclosed |