Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.51 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | YWHAG | P61981 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.46 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507048 | 0.91 | PPARA (0.60) | LCKKAT8ALOX15IGF1RPPARA | |
| SCHEMBL9506788 | 0.85 | PLA2G4B (0.60) | ALOX15IGF1R | |
| SCHEMBL10412008 | 0.83 | CYSLTR1 (0.54) | LCKALOX15IGF1RYWHAGAPP | |
| SCHEMBL9003598 | 0.83 | KAT8 (0.60) | LCKKAT8ALOX15IGF1RPPARA | |
| SCHEMBL9003186 | 0.83 | KAT8 (0.60) | LCKKAT8ALOX15IGF1RPPARA | |
| SCHEMBL9506806 | 0.83 | KMT2A (0.56) | ALOX15IGF1RACHESGMS1SGMS2 | |
| SCHEMBL9003322 | 0.83 | KAT8 (0.60) | LCKKAT8ALOX15IGF1RPPARA | |
| SCHEMBL13965427 | 0.82 | KAT8 (0.49) | LCKKAT8MCL1KLKB1CTSB | |
| SCHEMBL14770776 | 0.82 | MCL1 (0.57) | MCL1PTPN11 | |
| SCHEMBL13974898 | 0.81 | IGF1R (0.55) | LCKKAT8ALOX15IGF1RMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | claimed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | claimed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |