Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506788 | 0.86 | PLA2G4B (0.60) | PLA2G4BIGF1RALOX15NR1H4 | |
| SCHEMBL10412008 | 0.84 | CYSLTR1 (0.54) | PLA2G4BIGF1RALOX15NR1H4 | |
| SCHEMBL9325739 | 0.84 | PLA2G2A (0.68) | PLA2G4B | |
| SCHEMBL9326039 | 0.84 | PLA2G2A (0.68) | PLA2G4B | |
| SCHEMBL9326048 | 0.84 | PLA2G2A (0.68) | PLA2G4B | |
| SCHEMBL9853952 | 0.83 | NR4A2 (0.69) | KMT2APLA2G4BNR4A2NR1H4AKR1C3 | |
| SCHEMBL4509654 | 0.83 | KMT2A (0.77) | KMT2APLA2G4BNR4A2NR1H4AKR1C3 | |
| SCHEMBL9507025 | 0.83 | LCK (0.61) | IGF1RALOX15ACHESGMS1SGMS2 | |
| SCHEMBL10412747 | 0.82 | CYSLTR1 (0.57) | PLA2G4BIGF1RALOX15NR1H4 | |
| SCHEMBL9507048 | 0.82 | PPARA (0.60) | IGF1RALOX15ACHESGMS1SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310126-B1 | DERIVATIVES OF PYROCATECHOL-CARBOXYLIC ACID, THEIR PREPARATION AND USE AS ACTIVE INGREDIENTS IN MEDICINES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-08-18 | — | — | EP | claimed |
| EP-0310126-A2 | Derivatives of pyrocatechol-carboxylic acid, their preparation and use as active ingredients in medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-05 | — | — | EP | claimed |
| US-5191108-A | Lipoxygenase inhibitors, antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5025036-A | Antiinflammatory agents, gastrointestinal, cardiovascular and skin disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-06-18 | — | — | US | disclosed |