Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10722613 | 0.93 | POLB (0.61) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL8173951 | 0.91 | POLB (0.60) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL8173908 | 0.87 | ABCB1 (0.64) | POLBCYP3A4CYP2C9SMN1; SMN2CYP2C19 | |
| SCHEMBL10721527 | 0.85 | POLB (0.60) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL10719218 | 0.84 | POLB (0.58) | POLBCYP3A4CYP2C9HTTCYP2C19 | |
| SCHEMBL8426425 | 0.83 | POLB (0.75) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| Rh-5849 SCHEMBL1538531 | 0.83 | POLB (1.00) | POLBCYP3A4CYP2C9SMN1; SMN2ABCB1 | |
| SCHEMBL9507296 | 0.81 | POLB (0.73) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL9509705 | 0.81 | POLB (0.67) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL8179825 | 0.80 | POLB (0.71) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361645-B1 | ORGANIC HYDRAZINE DERIVATIVES FOR PHARMACEUTICAL USE | ROHM AND HAAS COMPANY (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0236618-B1 | INSECTICIDAL N'-SUBSTITUTED-N,N'-DIACYLHYDRAZINES | ROHM AND HAAS COMPANY (US) | 1991-02-27 | — | — | EP | disclosed |
| EP-0361645-A2 | Organic hydrazine derivatives for pharmaceutical use | ROHM AND HAAS COMPANY (US) | 1990-04-04 | — | — | EP | disclosed |