Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179825 | 0.84 | POLB (0.71) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL8426425 | 0.83 | POLB (0.75) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL9756061 | 0.82 | SMN1; SMN2 (0.70) | POLBCYP3A4SMN1; SMN2ABCB1 | |
| SCHEMBL9507427 | 0.81 | POLB (0.71) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| Rh-5849 SCHEMBL1538531 | 0.80 | POLB (1.00) | POLBCYP3A4CYP2C9SMN1; SMN2ABCB1 | |
| SCHEMBL8179586 | 0.80 | POLB (0.65) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL9507296 | 0.79 | POLB (0.73) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL9756244 | 0.78 | POLB (0.67) | POLBCYP3A4CYP2C9SMN1; SMN2RECQL | |
| SCHEMBL9825459 | 0.77 | POLB (0.85) | POLBCYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL9825457 | 0.77 | POLB (0.85) | POLBCYP3A4CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361645-B1 | ORGANIC HYDRAZINE DERIVATIVES FOR PHARMACEUTICAL USE | ROHM AND HAAS COMPANY (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0234944-B1 | INSECTICIDAL N'-SUBSTITUTED-N-ACYL-N'-ALKYLCARBONYLHYDRAZINES | ROHM AND HAAS COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| EP-0361645-A2 | Organic hydrazine derivatives for pharmaceutical use | ROHM AND HAAS COMPANY (US) | 1990-04-04 | — | — | EP | disclosed |