SCHEMBL9507644

SCHEMBL9507644

Clc1ccc2c(c1)Sc1cc(-c3ccccc3)c(Cl)cc1S2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 0.41
ACHE P22303 2/20 0.41
NOX1 Q9Y5S8 1/20 0.41
HPGD P15428 2/20 0.41
NPC1 O15118 2/20 0.41
ALDH1A1 P00352 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TP53 P04637 1/20 0.41
TSHR P16473 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HSD17B10 Q99714 1/20 0.41
KMT2A Q03164 3/20 0.40
KDM4E B2RXH2 2/20 0.40
CYP2A6 P11509 1/20 0.39
HSD11B1 P28845 1/20 0.39
RPS6KA3 P51812 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CSNK2A1 P68400 2/20 0.38
CYP1A2 P05177 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508960 0.80 AHR (0.45) TP53CYP2A6HSD11B1CYP1A2LMNA
SCHEMBL9508168 0.79 CYP2A6 (0.39) HPGDNPC1RAB9ATP53TSHR
SCHEMBL9507758 0.79 BCHE (0.59) BCHEACHENOX1HPGDRAB9A
SCHEMBL4929830 0.77
SCHEMBL9511257 0.77 BCHE (0.48) BCHEACHENOX1HPGDALDH1A1
SCHEMBL9508955 0.77 BCHE (0.48) BCHEACHENOX1HPGDALDH1A1
SCHEMBL9511254 0.75 BACE1 (0.44) BCHEACHENOX1HPGDALDH1A1
SCHEMBL17876644 0.74 CYP2A6 (0.60) BCHEACHENOX1HPGDNPC1
SCHEMBL2934398 0.73 CYP2A6 (0.58) HPGDNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL510771 0.73 AHR (0.61) HPGDNPC1ALDH1A1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed
EP-0399293-A1 Process for preparing 2-chloro-4-nitro-alkylbenzene BAYER AG (DE) 1990-11-28 EP disclosed