Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 19/20 | 0.61 |
| ▸ | ADRB3 known ✓ | P13945 | 16/20 | 0.61 |
| ▸ | ADRB1 known ✓ | P08588 | 15/20 | 0.57 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.56 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.56 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.56 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.56 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | FPR3 | P25089 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9763577 | 0.84 | ADRB2 (0.69) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL9510776 | 0.83 | ADRB2 (0.66) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL9763032 | 0.83 | ADRB2 (0.66) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL10390263 | 0.81 | ADRB2 (0.66) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL28044430 | 0.79 | ADRB2 (0.85) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL6256282 | 0.78 | ADRB2 (0.71) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL9763132 | 0.78 | ADRB2 (0.70) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL6256285 | 0.78 | ADRB2 (0.71) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL9762696 | 0.77 | ADRB2 (0.73) | ADRB2ADRB3ADRB1KDM4EHTR1A | |
| SCHEMBL9508707 | 0.75 | ADRB2 (0.72) | ADRB2ADRB3ADRB1KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322164-B1 | ETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-09-22 | — | — | EP | disclosed |
| US-5039697-A | Adrenergic stimulants, bronchodilators | GLAXO GROUP LIMITED (GB) | 1991-08-13 | — | — | US | disclosed |
| US-5032609-A | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1991-07-16 | — | — | US | disclosed |
| US-5002966-A | Adrenergic Stimulants | GLAXO GROUP LIMITED (GB) | 1991-03-26 | — | — | US | disclosed |
| EP-0322164-A2 | Ethanolamine derivatives | GLAXO GROUP LIMITED (GB) | 1989-06-28 | — | — | EP | disclosed |