SCHEMBL9508157

SCHEMBL9508157

COC(=O)c1cc2c(c(Cl)c1SC(C)=O)Sc1cc(C(=O)OC)c(SC(C)=O)c(Cl)c1S2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SERPINH1 P50454 1/20 0.35
ABL1 P00519 1/20 0.35
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA7 P43166 2/20 0.34
CA9 Q16790 2/20 0.34
CA14 Q9ULX7 2/20 0.34
GAA P10253 1/20 0.33
PTGS2 P35354 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
NR4A2 P43354 2/20 0.31
KDM4E B2RXH2 2/20 0.31
PDK2 Q15119 2/20 0.31
PDK4 Q16654 2/20 0.31
NQO2 P16083 3/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
PDK1 Q15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9511327 0.66 GAA (0.45) SERPINH1ABL1CA12CA1CA2
SCHEMBL9511441 0.66 GAA (0.45) SERPINH1ABL1CA12CA1CA2
SCHEMBL523584 0.60 ABL1 (0.57) ABL1CA12CA1CA2CA7
SCHEMBL1953848 0.60 GAA (0.58) ABL1CA12CA1CA2CA7
SCHEMBL70011 0.60 GAA (0.58) ABL1CA12CA1CA2CA7
SCHEMBL9508968 0.60 MEN1 (0.33) MEN1KMT2A
SCHEMBL20889413 0.60 ABL1 (0.44) SERPINH1ABL1GAARXFP1NR4A2
SCHEMBL829753 0.59 CA12 (0.54) ABL1CA12CA1CA2CA7
SCHEMBL71501 0.59 GAA (0.52) ABL1CA12CA1CA2CA7
SCHEMBL23898722 0.59 ABL1 (0.46) ABL1CA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0399293-B1 PROCESS FOR PREPARING 2-CHLORO-4-NITRO-ALKYLBENZENE BAYER AG (DE) 1993-09-01 EP disclosed
US-5095157-A Friedel-crafts catalyst BAYER AKTIENGESELLSCHAFT (DE) 1992-03-10 US disclosed