Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42801 | 0.95 | — | — | |
| SCHEMBL13824462 | 0.95 | — | — | |
| SCHEMBL13824246 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL10792650 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL27831356 | 0.90 | ALDH1A1 (0.46) | ALDH1A1TDP1HTTGPR84SPHK1 | |
| Isopropyl Alcohol SCHEMBL9510797 | 0.90 | ALDH1A1 (0.46) | ALDH1A1TDP1HTTGPR84SPHK1 | |
| SCHEMBL4303715 | 0.87 | — | — | |
| SCHEMBL4171750 | 0.87 | — | — | |
| SCHEMBL2357309 | 0.87 | — | — | |
| SCHEMBL16390024 | 0.85 | HTT (0.55) | HTTGPR84CYP2D6SPHK1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014168633-A1 | COMPOSITES FORMED FROM AN ABSORPTIVE FILLER AND A POLYURETHANE | BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED (AU) | 2014-10-16 | — | — | WO | claimed |
| US-12043694-B2 | Method for producing polyurethane hard foam composite elements using Mannich polyols | BASF SE (DE) | 2024-07-23 | — | — | US | disclosed |
| US-12037443-B2 | Polymeric materials with improved environmental durability | Westlake Royal Building Products Inc. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12024583-B2 | Surfactant-free filled polyurethane foam and method of making same | Westlake Royal Building Products Inc. (US) | 2024-07-02 | — | — | US | disclosed |
| US-20240110037-A1 | BUILDING MATERIAL | RESHUFFLE CONSULTING, LLC | 2024-04-04 | — | — | US | disclosed |
| EP-3953406-B1 | POLYURETHANE AND PROCESS FOR MAKING | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| US-20240001661-A1 | HIGHLY-FILLED POLYURETHANE COMPOSITES WITH FIBER REINFORCEMENT | Westlake Royal Building Products Inc. (US) | 2024-01-04 | — | — | US | disclosed |
| CN-113631607-B | Polyurethane and method for producing same | 陶氏环球技术有限责任公司 | 2023-10-27 | — | — | CN | disclosed |
| US-20230295370-A1 | FILLED POLYURETHANE OR POLYISOCYANURATE FOAM AND METHOD OF MAKING SAME | Westlake Royal Building Products Inc. (US) | 2023-09-21 | — | — | US | disclosed |
| EP-3728378-B1 | METHOD FOR THE PREPARATION OF POLYURETHANE HARD FOAM COMPOSITE ELEMENTS USING MANNICH POLYOLS | BASF SE (DE) | 2023-08-16 | — | — | EP | disclosed |
| WO-2016018226-A1 | THE USE OF EVAPORATIVE COOLANTS TO MANUFACTURE FILLED POLYURETHANE COMPOSITES | CROCCO GUY (US) | 2016-02-04 | — | — | WO | disclosed |
| US-20150267029-A1 | COMPOSITES FORMED FROM AN ABSORPTIVE FILLER AND A POLYURETHANE | EM RESOURCES LLC | 2015-09-24 | — | — | US | disclosed |
| WO-2014168633-A1 | COMPOSITES FORMED FROM AN ABSORPTIVE FILLER AND A POLYURETHANE | BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED (AU) | 2014-10-16 | — | — | WO | disclosed |
| EP-0352775-B1 | POLYOLS COMPRISING AN ALKOXYLATED MANNICH CONDENSATE AND PROCESS FOR PREPARING THE SAME | THE DOW CHEMICAL COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5120815-A | TERTIARY AMINE-CONTAINING POLYOLS PREPARED IN A MANNICH CONDENSATION REACTION USING A MIXTURE OF ALKANOLAMINES | THE DOW CHEMICAL COMPANY (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0405557-A2 | A process for preparing a mannich condensate polyether polyol and polyurethanes therefrom | THE DOW CHEMICAL COMPANY (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4939182-A | FLAME RETARDERS | THE DOW CHEMICAL COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0352776-A2 | Melamine-alkanolamine condensates, polyols and polyurethanes prepared therefrom and process for preparing the same | THE DOW CHEMICAL COMPANY (US) | 1990-01-31 | — | — | EP | disclosed |
| EP-0352775-A1 | Polyols comprising an alkoxylated mannich condensate and process for preparing the same | THE DOW CHEMICAL COMPANY (US) | 1990-01-31 | — | — | EP | disclosed |
| US-4883826-A | Tertiary amine-containing polyols prepared in a mannich condensation reaction using a mixture of alkanolamines | THE DOW CHEMICAL COMPANY (US) | 1989-11-28 | — | — | US | disclosed |