Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.40 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.40 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.40 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.40 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.40 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.35 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14290472 | 0.98 | CYP2D6 (0.48) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| SCHEMBL114270 | 0.78 | CYP2D6 (0.48) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| SCHEMBL8411989 | 0.77 | CYP2D6 (0.42) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| Bromide SCHEMBL3252964 | 0.76 | CYP2D6 (0.55) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| Bromide SCHEMBL20591841 | 0.76 | CYP2D6 (0.55) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| Bromide SCHEMBL2900871 | 0.76 | CYP2D6 (0.55) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| SCHEMBL1855483 | 0.74 | CYP2D6 (0.46) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| SCHEMBL12879844 | 0.74 | CYP2D6 (0.46) | CYP2D6CYP2C19CHRM2ADRA2ADRD1 | |
| SCHEMBL1630012 | 0.74 | — | — | |
| SCHEMBL29635663 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292797-B1 | PROCESS FOR PREPARING PARTICLES OF OLEFIN-MALEIC ANHYDRIDE COPOLYMER | Kao Corporation (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-4795792-A | CATIONIC DISPERSANT | KAO CORPORATION (JP) | 1989-01-03 | — | — | US | disclosed |
| EP-0292797-A2 | Process for preparing particles of olefin-maleic anhydride copolymer | Kao Corporation (JP) | 1988-11-30 | — | — | EP | disclosed |