Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.55 |
| ▸ | CETP | P11597 | 3/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021044 | 1.00 | NPC1 (0.56) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL9508881 | 1.00 | NPC1 (0.56) | NPC1RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL9508817 | 0.86 | TNNC1 (0.49) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL9508811 | 0.86 | TNNC1 (0.49) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL9508291 | 0.82 | TNNC1 (0.50) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL9508285 | 0.82 | TNNC1 (0.50) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL9506968 | 0.81 | NPC1 (0.64) | NPC1RAB9AHDAC1CETP | |
| SCHEMBL9504695 | 0.79 | TNNC1 (0.51) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL9504807 | 0.79 | TNNC1 (0.51) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL9504363 | 0.79 | TNNC1 (0.51) | HDAC3HDAC1HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161939-B1 | ARYLHYDROXAMATES | E.R. Squibb & Sons, Inc. (US) | 1993-07-21 | — | — | EP | disclosed |
| CN-85104470-A | The method for preparing arythydroxamtes | — | 1986-10-01 | — | — | CN | disclosed |
| US-4607053-A | L2POXYGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-19 | — | — | US | disclosed |
| EP-0161939-A2 | Arylhydroxamates | E.R. Squibb & Sons, Inc. (US) | 1985-11-21 | — | — | EP | disclosed |