SCHEMBL9509225

SCHEMBL9509225

CCCOc1ccc(C#Cc2ccc(-c3ccc(CC)cc3)c(F)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ACACB O00763 12/20 0.43
S1PR1 P21453 2/20 0.39
S1PR3 Q99500 2/20 0.39
MCHR1 Q99705 1/20 0.39
MGAM O43451 4/20 0.38
GAA P10253 4/20 0.38
SI P14410 4/20 0.38
MGAM2 Q2M2H8 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9512372 0.95 S1PR1 (0.44) ACACBS1PR1S1PR3MCHR1
SCHEMBL9508764 0.93 RARB (0.44) ACACBS1PR1S1PR3
SCHEMBL9508758 0.91 ACACB (0.48) ACACBS1PR1S1PR3MCHR1
SCHEMBL9512486 0.90 ACACB (0.41) ACACB
SCHEMBL9512415 0.89 ACACB (0.46) ACACBS1PR1S1PR3
SCHEMBL10511036 0.88 RARB (0.47) ACACBS1PR1S1PR3
SCHEMBL9508714 0.88 RARB (0.50) ACACBS1PR1S1PR3
SCHEMBL9512246 0.87 RARB (0.52) ACACBS1PR1S1PR3
SCHEMBL9510037 0.87 RARB (0.52) ACACBS1PR1S1PR3
SCHEMBL9512526 0.87 APP (0.43) ACACBMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP disclosed