SCHEMBL9510190

SCHEMBL9510190

CCCC[C@H]1CC[C@H](c2ccc(C#Cc3ccc(OC(F)(F)F)cc3)cc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.40
RCOR1 Q9UKL0 1/20 0.40
CYP2C9 P11712 2/20 0.39
ACACB O00763 1/20 0.38
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
MEN1 O00255 1/20 0.37
MAPK1 P28482 1/20 0.37
KMT2A Q03164 1/20 0.37
RAB9A P51151 1/20 0.37
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HRH3 Q9Y5N1 1/20 0.35
ESR2 Q92731 1/20 0.35
SPHK1 Q9NYA1 1/20 0.34
TSHR P16473 1/20 0.34
DRD2 P14416 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9508941 0.96 KDM1A (0.39) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL9508932 0.95 KDM1A (0.38) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL9509020 0.95 KDM1A (0.38) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL9510189 0.95 KDM1A (0.38) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL8375654 0.92 CYP2C9 (0.46) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL8407553 0.92 KDM1A (0.45) KDM1ARCOR1CYP2C9ALDH1A1LMNA
SCHEMBL9061117 0.92 KDM1A (0.45) KDM1ARCOR1CYP2C9ALDH1A1LMNA
SCHEMBL3168916 0.91 CYP2C9 (0.34) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL3168907 0.91 CYP2C9 (0.34) KDM1ARCOR1CYP2C9ACACBALDH1A1
SCHEMBL6456850 0.90 RAB9A (0.37) KDM1ARCOR1CYP2C9ACACBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP claimed