SCHEMBL9510227

SCHEMBL9510227

CCCCCOc1ccc(C#Cc2ccc(CCC)c(F)c2F)cc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NR5A1 Q13285 1/20 0.41
LTA4H P09960 3/20 0.40
KDM4E B2RXH2 2/20 0.40
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
RARB P10826 3/20 0.38
ACACB O00763 2/20 0.38
TP53 P04637 1/20 0.38
TSHR P16473 1/20 0.38
CYSLTR2 Q9NS75 1/20 0.37
CYSLTR1 Q9Y271 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CNR2 P34972 2/20 0.37
PLA2G4B P0C869 1/20 0.37
MCHR1 Q99705 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9510156 0.97 ACACB (0.39) NR5A1LTA4HKDM4EALDH1A1HPGD
SCHEMBL9512534 0.95 CNR2 (0.42) NR5A1LTA4HKDM4EALDH1A1HPGD
SCHEMBL9512426 0.93 CNR2 (0.40) NR5A1LTA4HKDM4EALDH1A1HPGD
SCHEMBL9512289 0.92 ACACB (0.39) NR5A1LTA4HKDM4EALDH1A1HPGD
SCHEMBL9512429 0.92 ACACB (0.43) ACACBMCHR1
SCHEMBL10509743 0.92 CYSLTR2 (0.37) RARBACACBCYSLTR2CYSLTR1CNR2
SCHEMBL9511360 0.91 ACACB (0.41) NR5A1ACACBCYSLTR2CYSLTR1CNR2
SCHEMBL9510163 0.91 NR5A1 (0.42) NR5A1LTA4HKDM4EALDH1A1HPGD
SCHEMBL10519853 0.90 ACACB (0.39) ACACBCYSLTR2CYSLTR1
SCHEMBL9512387 0.90 ACACB (0.41) ACACBCYP3A4CYP2D6MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0308438-B1 LIQUID CRYSTAL PHASE CONTAINING TOLANES MERCK PATENT GmbH (DE) 1993-09-29 EP disclosed