Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508519 | 0.70 | SMN1; SMN2 (0.41) | L3MBTL1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5695668 | 0.68 | CYP1A2 (0.37) | L3MBTL1CYP1A2CYP3A4CYP2D6PRMT1 | |
| SCHEMBL934106 | 0.66 | KMT2A (0.46) | L3MBTL1TSHRCYP3A4CYP2D6MAPK1 | |
| SCHEMBL16391353 | 0.66 | KMT2A (0.46) | L3MBTL1TSHRCYP3A4CYP2D6LMNA | |
| SCHEMBL490867 | 0.65 | KMT2A (0.44) | L3MBTL1TSHRCYP3A4CYP2D6MAPK1 | |
| SCHEMBL9068773 | 0.64 | CYP1A2 (0.53) | EPHX1CYP1A2CYP3A4CYP2D6PRMT1 | |
| SCHEMBL28223055 | 0.64 | CYP1A2 (0.41) | EPHX1TSHRCYP1A2CYP2D6RECQL | |
| SCHEMBL16447678 | 0.64 | KMT2A (0.43) | L3MBTL1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11851694 | 0.62 | KCNN4 (0.46) | L3MBTL1CYP1A2CYP3A4CYP2D6PRMT1 | |
| SCHEMBL16407736 | 0.62 | KMT2A (0.42) | L3MBTL1TSHRCYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358305-B1 | MERCAPTO-PHENYLALCANOYLAMINO ACID AMIDES, THEIR PREPARATION AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-5124322-A | Antiarthritic agents | BEECHAM GROUP P.L.C. (GB) | 1992-06-23 | — | — | US | disclosed |
| EP-0358305-A1 | Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1990-03-14 | — | — | EP | disclosed |