Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9663254 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2HIF1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5695668 | 0.85 | CYP1A2 (0.37) | SMN1; SMN2CYP1A2CYP3A4CYP2D6PRMT1 | |
| SCHEMBL6158106 | 0.74 | SMN1; SMN2 (0.48) | SMN1; SMN2HIF1ACYP1A2CYP3A4TRPA1 | |
| SCHEMBL24236755 | 0.72 | TRPA1 (0.47) | SMN1; SMN2HIF1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21834962 | 0.72 | TRPA1 (0.47) | SMN1; SMN2HIF1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21834963 | 0.72 | TRPA1 (0.47) | SMN1; SMN2HIF1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14713246 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2HIF1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9173979 | 0.71 | LMNA (0.36) | SMN1; SMN2HIF1ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2466818 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2HIF1ATRPA1GAAPPARG | |
| SCHEMBL9510972 | 0.70 | L3MBTL1 (0.37) | CYP1A2CYP3A4CYP2D6PRMT1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358305-B1 | MERCAPTO-PHENYLALCANOYLAMINO ACID AMIDES, THEIR PREPARATION AND THEIR USE AS COLLAGENASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1993-08-25 | — | — | EP | disclosed |
| US-5124322-A | Antiarthritic agents | BEECHAM GROUP P.L.C. (GB) | 1992-06-23 | — | — | US | disclosed |
| EP-0358305-A1 | Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors | BEECHAM GROUP PLC (GB) | 1990-03-14 | — | — | EP | disclosed |