Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11327486 | 0.82 | GAA (0.57) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL9511671 | 0.82 | GAA (0.57) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL5466546 | 0.82 | GAA (0.57) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL7297828 | 0.79 | GAA (0.55) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL11337711 | 0.79 | GAA (0.55) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL24179180 | 0.78 | GAA (0.54) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL10476939 | 0.78 | GAA (0.54) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL20867680 | 0.78 | GAA (0.54) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL9380800 | 0.78 | GAA (0.54) | GAAMOGAT2MEN1LMNAMAPT | |
| SCHEMBL7298355 | 0.77 | GAA (0.52) | GAAMOGAT2MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564520-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-13 | — | — | EP | disclosed |
| WO-1992011011-A1 | USE OF CERTAIN GLUTARIMIDE DERIVATIVES IN THE TREATMENT OF DEPRESSION AND MANIA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-09 | — | — | WO | disclosed |
| EP-0492021-A1 | Use of certain 1,2-benzoisothiazol-3(2H)-1,1-dioxide derivatives in the treatment of depression and mania | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |