Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10476939 | 1.00 | GAA (0.54) | GAAMOGAT2ALDH1A1KDM4EMEN1 | |
| SCHEMBL7133561 | 0.79 | GAA (0.35) | GAAKDM4EMEN1KMT2AMAPT | |
| SCHEMBL5466546 | 0.78 | GAA (0.57) | GAAMOGAT2ALDH1A1MEN1KMT2A | |
| SCHEMBL11327486 | 0.78 | GAA (0.57) | GAAMOGAT2MEN1KMT2ALMNA | |
| SCHEMBL9511664 | 0.78 | GAA (0.57) | GAAMOGAT2MEN1KMT2ALMNA | |
| SCHEMBL9511671 | 0.78 | GAA (0.57) | GAAMOGAT2MEN1KMT2ALMNA | |
| SCHEMBL24179180 | 0.77 | GAA (0.54) | GAAMOGAT2MEN1KMT2ALMNA | |
| SCHEMBL7297828 | 0.75 | GAA (0.55) | GAAMOGAT2ALDH1A1KDM4EMEN1 | |
| SCHEMBL11337711 | 0.75 | GAA (0.55) | GAAMOGAT2MEN1KMT2ALMNA | |
| SCHEMBL20867680 | 0.74 | GAA (0.54) | GAAMOGAT2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4880926-A | CRYSTALLIZATION, CAMPHORSULFONIC ACIDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-11-14 | — | — | US | claimed |
| EP-0304684-A1 | Process for the preparation of benzoxazine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-03-01 | — | — | EP | claimed |
| JP-2031695-A | — | — | None | — | — | JP | disclosed |
| JP-1131168-A | — | — | None | — | — | JP | disclosed |
| JP-1180867-A | — | — | None | — | — | JP | disclosed |
| US-9663502-B2 | 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease | LYCERA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160304505-A1 | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME LLC | 2016-10-20 | — | — | US | disclosed |
| EP-0273399-B1 | Optically active 2,3-dihydrobenzoaxine derivatives and process for preparing the same | DAIICHI SEIYAKU CO (JP) | 1994-08-17 | — | — | EP | disclosed |
| JP-H0231695-A | OPTICAL RESOLUTION USING MICROORGANISM | DAI ICHI SEIYAKU CO LTD | 1990-02-01 | — | — | JP | disclosed |
| US-4895944-A | BACTERICIDE OFLOXACIN | DAIICHI SEIYAKU COMPANY, LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| US-4880926-A | CRYSTALLIZATION, CAMPHORSULFONIC ACIDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| US-4880926-A | CRYSTALLIZATION, CAMPHORSULFONIC ACIDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| JP-H01180867-A | OPTICAL RESOLUTION | DAI ICHI SEIYAKU CO LTD | 1989-07-18 | — | — | JP | disclosed |
| JP-H01131168-A | PRODUCTION OF BENZOOXAZINE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1989-05-24 | — | — | JP | disclosed |
| EP-0304684-A1 | Process for the preparation of benzoxazine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-03-01 | — | — | EP | disclosed |
| EP-0304684-A1 | Process for the preparation of benzoxazine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-03-01 | — | — | EP | disclosed |
| EP-0273399-A1 | Optically active 2,3-dihydrobenzoaxine derivatives and process for preparing the same | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-07-06 | — | — | EP | disclosed |
| JP-H00231695-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304505-A1 | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORA, RORB, RORC | GAA 400/4885MOGAT2 569/4885ALDH1A1 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.