Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 14/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 14/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515364 | 0.98 | LTB4R (0.48) | LTB4RLTB4R2RXRARXRBRXRG | |
| SCHEMBL9513226 | 0.96 | LTB4R (0.51) | LTB4RLTB4R2RXRARXRBRXRG | |
| SCHEMBL9511696 | 0.95 | LTB4R (0.45) | LTB4RLTB4R2RXRARXRBRXRG | |
| SCHEMBL9513292 | 0.93 | LTB4R (0.44) | LTB4RLTB4R2RXRARXRBRXRG | |
| SCHEMBL9514439 | 0.91 | LTB4R (0.42) | LTB4RLTB4R2MCL1PTGESALOX5 | |
| SCHEMBL9513150 | 0.91 | LTB4R (0.41) | LTB4RLTB4R2MCL1PTGESALOX5 | |
| SCHEMBL9512210 | 0.89 | LTB4R (0.41) | LTB4RLTB4R2RXRARXRBRXRG | |
| SCHEMBL9512193 | 0.89 | LTB4R (0.40) | LTB4RLTB4R2MCL1PTGESALOX5 | |
| SCHEMBL9513650 | 0.88 | LTB4R (0.39) | LTB4RLTB4R2MCL1PTGESALOX5 | |
| SCHEMBL9513804 | 0.88 | LTB4R (0.39) | LTB4RLTB4R2MCL1PTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342664-B1 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | SEARLE & CO (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5093353-A | 2,2-di-substituted benzopyran leukotriene-D4 antagonists | G. D. SEARLE & CO. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |