Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512853 | 1.00 | TSHR (0.53) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8297430 | 0.84 | TSHR (0.60) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9363967 | 0.79 | TSHR (0.55) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9363974 | 0.79 | TSHR (0.55) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL112377 | 0.77 | TSHR (0.65) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL29787113 | 0.77 | TSHR (0.65) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL31004827 | 0.77 | TSHR (0.65) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL699212 | 0.77 | TSHR (0.65) | TSHRPKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9512266 | 0.76 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1LMNA | |
| SCHEMBL9512280 | 0.76 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569409-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-11-18 | — | — | EP | claimed |