Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510816 | 0.85 | MAPT (0.63) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL9817347 | 0.80 | GAA (0.74) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL15427115 | 0.79 | MAPT (1.00) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL24025329 | 0.79 | MAPT (0.63) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL24025347 | 0.78 | MAPT (0.61) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL8267173 | 0.77 | NPC1 (0.90) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL9512456 | 0.77 | GAA (0.71) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL10192186 | 0.77 | NPC1 (1.00) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL8267184 | 0.75 | HTT (0.74) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL345038 | 0.74 | MAPT (0.67) | MAPTNPC1RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371876-B1 | Isoxazoles and isoxazolines with an anticonvulsive activity, and pharmaceutical compositions containing them | NOVAPHARME (FR) | 1993-11-24 | — | — | EP | claimed |
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | claimed |