Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13321368 | 0.87 | NPC1 (0.64) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL19376953 | 0.85 | MAPT (0.57) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL25206621 | 0.81 | ALDH1A1 (0.59) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL8267184 | 0.81 | HTT (0.74) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL9512988 | 0.80 | MAPT (0.65) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL10192186 | 0.80 | NPC1 (1.00) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL10009062 | 0.78 | GAA (0.65) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL24025346 | 0.78 | MAPT (0.58) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL8267173 | 0.77 | NPC1 (0.90) | GAANPC1RAB9AALDH1A1HTT | |
| SCHEMBL25257220 | 0.77 | MAPT (0.56) | GAANPC1RAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | disclosed |