Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513405 | 1.00 | ATM (0.52) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL9513399 | 1.00 | ATM (0.52) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL9511334 | 0.87 | ATM (0.53) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL9513414 | 0.87 | ATM (0.53) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL9513430 | 0.87 | ATM (0.53) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL1200736 | 0.83 | ATM (0.62) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL1200738 | 0.83 | ATM (0.62) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL1200775 | 0.83 | ATM (0.62) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL7441310 | 0.79 | LMNA (0.49) | ATMSMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL24661545 | 0.74 | SMN1; SMN2 (0.62) | ATMSMN1; SMN2LMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254545-B1 | DIAMINE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-06 | — | — | EP | disclosed |
| EP-0254545-A2 | Diamine compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-01-27 | — | — | EP | disclosed |