Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 7/20 | 0.72 |
| ▸ | PARP1 | P09874 | 6/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | MDM4 | O15151 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29429765 | 1.00 | DHPS (0.72) | DHPSPARP1NPC1RAB9ACYP1A2 | |
| SCHEMBL31156435 | 0.87 | PARP1 (0.71) | DHPSPARP1NPC1RAB9AMAPK1 | |
| SCHEMBL3194860 | 0.87 | DHPS (0.67) | DHPSPARP1NPC1RAB9ACYP1A2 | |
| SCHEMBL13483893 | 0.84 | DHPS (1.00) | DHPSPARP1NPC1RAB9A | |
| SCHEMBL31156433 | 0.84 | DHPS (0.76) | DHPSPARP1NPC1RAB9ACYP1A2 | |
| SCHEMBL29901215 | 0.83 | MAPK1 (0.63) | DHPSPARP1MAPK1TRPV1 | |
| SCHEMBL4025098 | 0.83 | MAPK1 (0.63) | DHPSPARP1MAPK1TRPV1 | |
| SCHEMBL31156445 | 0.83 | DHPS (0.67) | DHPSPARP1NPC1RAB9AMAPK1 | |
| SCHEMBL9806209 | 0.83 | DHPS (0.70) | DHPSPARP1NPC1RAB9APARP14 | |
| SCHEMBL19977141 | 0.83 | DHPS (0.56) | DHPSPARP1NPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275762-B1 | Indole carboxamide derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1993-11-18 | — | — | EP | claimed |
| EP-0275221-B1 | N-(1H-INDOL-4-YL) BENZAMIDE DERIVATIVES, THEIR SALTS AND THEIR USE AS MEDICINES, AND COMPOSITION CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-04-17 | — | — | EP | claimed |
| EP-0213984-B1 | INDOLE CARBOXAMIDE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-01-09 | — | — | EP | claimed |
| EP-0275762-A1 | Indole carboxamide derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-07-27 | — | — | EP | claimed |
| EP-0275221-A2 | N-(1H-indol-4-yl) benzamide derivatives, their salts and their use as medicines, and composition containing them | ROUSSEL-UCLAF (FR) | 1988-07-20 | — | — | EP | claimed |
| EP-0213984-A1 | Indole carboxamide derivatives, their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-03-11 | — | — | EP | claimed |
| EP-0275762-B1 | Indole carboxamide derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1993-11-18 | — | — | EP | disclosed |
| EP-0275221-B1 | N-(1H-INDOL-4-YL) BENZAMIDE DERIVATIVES, THEIR SALTS AND THEIR USE AS MEDICINES, AND COMPOSITION CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-04-17 | — | — | EP | disclosed |
| EP-0213984-B1 | INDOLE CARBOXAMIDE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-01-09 | — | — | EP | disclosed |
| US-4908367-A | Antiarrythmic agents | Uclaf, Roussel (FR) | 1990-03-13 | — | — | US | disclosed |
| EP-0275762-A1 | Indole carboxamide derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-07-27 | — | — | EP | disclosed |
| EP-0275221-A2 | N-(1H-indol-4-yl) benzamide derivatives, their salts and their use as medicines, and composition containing them | ROUSSEL-UCLAF (FR) | 1988-07-20 | — | — | EP | disclosed |
| EP-0275221-A2 | N-(1H-indol-4-yl) benzamide derivatives, their salts and their use as medicines, and composition containing them | ROUSSEL-UCLAF (FR) | 1988-07-20 | — | — | EP | disclosed |
| EP-0213984-A1 | Indole carboxamide derivatives, their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-03-11 | — | — | EP | disclosed |