SCHEMBL9513612

SCHEMBL9513612

Clc1cncc(Cl)c1.FB(F)F

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.44
TSHR P16473 1/20 0.39
CHRNB2 P17787 3/20 0.38
CHRNA4 P43681 3/20 0.38
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
MKNK1 Q9BUB5 1/20 0.35
MKNK2 Q9HBH9 1/20 0.35
FGFR1 P11362 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL197638 0.87
Water SCHEMBL28044737 0.84
SCHEMBL30129770 0.84
SCHEMBL28044800 0.84
Hydrochloric Acid SCHEMBL6069542 0.84
Water SCHEMBL28044696 0.81 HCAR2 (0.48) HCAR2TSHRCHRNB2CHRNA4CYP11B1
SCHEMBL27399560 0.80 HCAR2 (0.43) HCAR2TSHRCHRNB2CHRNA4CYP11B1
Cyanide SCHEMBL28048122 0.79 HCAR2 (0.46) HCAR2TSHRCHRNB2CHRNA4CYP11B1
Formaldehyde SCHEMBL28060910 0.79 HCAR2 (0.52) HCAR2TSHRCHRNB2CHRNA4CHRNB4
SCHEMBL28151623 0.77 HCAR2 (0.50) HCAR2TSHRCHRNB2CHRNA4CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0471755-B1 N-FLUOROPYRIDINIUM PYRIDINE HEPTAFLUORODIBORATE ALLIED SIGNAL INC (US) 1993-11-18 EP disclosed
US-5243080-A Ether and ester compounds ALLIEDSIGNAL INC. (US) 1993-09-07 US disclosed
US-5162587-A METHOD FOR FLUORINATING BY USING N-FLUOROPYRIDINIUM PYRIDINE HEPTAFLUORODIBORATE ALLIED-SIGNAL INC. 1992-11-10 US disclosed
WO-1992012983-A1 A METHOD OF FLUORINATING BY USING N-FLUOROPYRIDINIUM PYRIDINE HEPTAFLUORODIBORATE ALLIED-SIGNAL INC. (US) 1992-08-06 WO disclosed
US-5086190-A Heating and reacting androstadienes with the complexes in solvent ALLIED-SIGNAL INC. (US) 1992-02-04 US disclosed
US-4935519-A Fluorination agent ALLIED-SIGNAL INC. (US) 1990-06-19 US disclosed