⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321568 | 0.90 | — | — | |
| SCHEMBL9848516 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL9848489 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL9848427 | 0.85 | — | — | |
| SCHEMBL9513648 | 0.84 | — | — | |
| SCHEMBL9848509 | 0.84 | — | — | |
| SCHEMBL9848439 | 0.83 | — | — | |
| SCHEMBL9848396 | 0.82 | LMNA (0.60) | — | |
| SCHEMBL9848403 | 0.81 | — | — | |
| SCHEMBL9848467 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130178446-A1 | METHOD FOR DECREASING SEBUM PRODUCTION | MEDICIS PHARMACEUTICAL CORPORATION (US) | 2013-07-11 | — | — | US | disclosed |
| US-20130178446-A1 | METHOD FOR DECREASING SEBUM PRODUCTION | MEDICIS PHARMACEUTICAL CORPORATION (US) | 2013-07-11 | — | — | US | disclosed |
| US-8409595-B2 | Method for decreasing sebum production | MEDICIS PHARMACEUTICAL CORPORATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-8409595-B2 | Method for decreasing sebum production | MEDICIS PHARMACEUTICAL CORPORATION (US) | 2013-04-02 | — | — | US | disclosed |
| US-20100113601-A1 | METHOD FOR DECREASING SEBUM PRODUCTION | GRACEWAY PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113601-A1 | METHOD FOR DECREASING SEBUM PRODUCTION | GRACEWAY PHARMACEUTICALS, LLC (US) | 2010-05-06 | — | — | US | disclosed |
| US-7615230-B2 | Topical applying N-benzyl-N'-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide as ACAT inhibitor to treat oily skin; acylcoenzyme a cholesterol acyltransferase (ACAT) | GRACEWAY PHARMACEUTICALS, LLC (US) | 2009-11-10 | — | — | US | disclosed |
| US-7615230-B2 | Topical applying N-benzyl-N'-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide as ACAT inhibitor to treat oily skin; acylcoenzyme a cholesterol acyltransferase (ACAT) | GRACEWAY PHARMACEUTICALS, LLC (US) | 2009-11-10 | — | — | US | disclosed |
| EP-1673077-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING MALONAMIDE DERIVATIVES FOR DECREASING SEBUM PRODUCTION | WARNER LAMBERT CO (US) | 2008-10-01 | — | — | EP | disclosed |
| EP-0344425-B1 | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents | WARNER LAMBERT CO (US) | 1993-12-08 | — | — | EP | disclosed |