Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879584 | 1.00 | KDM1A (0.42) | KDM1AANPEPHTR2ASIGMAR1SLC6A2 | |
| SCHEMBL9515297 | 1.00 | KDM1A (0.42) | KDM1AANPEPHTR2ASIGMAR1SLC6A2 | |
| SCHEMBL9514031 | 1.00 | KDM1A (0.42) | KDM1AANPEPHTR2ASIGMAR1SLC6A2 | |
| Hydrochloric Acid SCHEMBL9516405 | 0.98 | KDM1A (0.44) | KDM1AANPEPHTR2ASIGMAR1SLC6A2 | |
| SCHEMBL28295419 | 0.84 | KDM1A (0.47) | KDM1AANPEPHTR2ASIGMAR1SLC6A2 | |
| SCHEMBL9514089 | 0.81 | KDM1A (0.44) | KDM1AANPEPHTR2ASIGMAR1 | |
| SCHEMBL8309860 | 0.76 | KDM1A (0.47) | KDM1AANPEPHTR2ASIGMAR1 | |
| SCHEMBL1643076 | 0.76 | KDM1A (0.47) | KDM1AANPEPHTR2ASIGMAR1 | |
| SCHEMBL8430139 | 0.76 | ANPEP (0.40) | KDM1AANPEP | |
| SCHEMBL1239150 | 0.76 | KDM1A (0.47) | KDM1AANPEPHTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378456-B1 | TETRALIN DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5106861-A | Method of using certain tetralin derivatives to produce analgesic relief | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5041673-A | Aminopeptidase inhibitors, immunomodulators, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0378456-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-07-18 | — | — | EP | disclosed |