Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644343 | 0.81 | CYP1A2 (0.50) | CYP1A2CYP2A6SIGMAR1KMT2AMEN1 | |
| SCHEMBL9423246 | 0.79 | MAPT (0.55) | CYP1A2KMT2AMEN1MAPTALPG | |
| SCHEMBL188307 | 0.78 | TSHR (0.42) | CYP1A2SIGMAR1KMT2AMEN1CNR1 | |
| SCHEMBL17541809 | 0.77 | TSHR (0.46) | CYP1A2SIGMAR1HRH3CNR1 | |
| SCHEMBL29560700 | 0.77 | CYP1A2 (0.65) | CYP1A2CYP2A6SIGMAR1HRH3KMT2A | |
| SCHEMBL6240981 | 0.77 | CYP1A2 (0.65) | CYP1A2CYP2A6SIGMAR1HRH3KMT2A | |
| SCHEMBL264237 | 0.76 | CNR1 (0.46) | CYP1A2CYP2A6SIGMAR1CNR1 | |
| Hydrogen Peroxide SCHEMBL28697848 | 0.74 | CYP1A2 (0.47) | CYP1A2SIGMAR1HDAC1HDAC8CNR1 | |
| SCHEMBL131160 | 0.74 | CYP1A2 (0.56) | CYP1A2CYP2A6SIGMAR1HRH3HDAC1 | |
| SCHEMBL29213229 | 0.74 | MAPK1 (0.54) | CYP1A2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022319-C | 1, 2, 3, 4-tetrahydronaphthalene derivatives, process for their preparation and their use as medicaments | MERRELL DOW PHARMA (US) | 1993-10-06 | — | — | CN | disclosed |
| EP-0378456-B1 | TETRALIN DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5106861-A | Method of using certain tetralin derivatives to produce analgesic relief | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5041673-A | Aminopeptidase inhibitors, immunomodulators, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0381902-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-16 | — | — | EP | disclosed |
| CN-1044460-A | Novel 1,2,3,4-tetralin derivative | MERRELL DOW PHARMA (US) | 1990-08-08 | — | — | CN | disclosed |
| EP-0378456-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-07-18 | — | — | EP | disclosed |