Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.43 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514129 | 0.81 | CYP1A2 (0.49) | CYP1A2CYP2A6KMT2AMEN1MAPT | |
| SCHEMBL9321479 | 0.76 | TSHR (0.45) | CYP1A2 | |
| SCHEMBL28028464 | 0.75 | DAO (0.50) | KMT2AMEN1MAPTDAO | |
| SCHEMBL28028731 | 0.75 | ALDH1A1 (0.46) | CYP1A2KMT2AMEN1MAPTDAO | |
| SCHEMBL9322428 | 0.75 | LOXL2 (0.42) | CYP1A2 | |
| SCHEMBL9423246 | 0.74 | MAPT (0.55) | CYP1A2KMT2AMEN1MAPTALPG | |
| SCHEMBL27673225 | 0.73 | CPA1 (0.47) | CYP1A2 | |
| SCHEMBL73253 | 0.73 | CPA1 (0.47) | CYP1A2 | |
| SCHEMBL4610282 | 0.73 | CYP1A2 (0.47) | CYP1A2CYP2A6KMT2AMEN1MAPT | |
| SCHEMBL10718683 | 0.73 | GSR (0.47) | CYP1A2CYP2A6KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109562107-A | Heterocyclic degrading ligand for target protein degradation | C4医药公司 | 2019-04-02 | — | — | CN | disclosed |
| EP-1377577-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | Sankyo Company Limited (JP) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002057264-A1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO COMPANY LIMITED (JP) | 2002-07-25 | — | — | WO | disclosed |