Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 16/20 | 0.62 |
| ▸ | METAP1 | P53582 | 7/20 | 0.61 |
| ▸ | REN | P00797 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514498 | 1.00 | METAP2 (0.62) | METAP2METAP1REN | |
| SCHEMBL9514503 | 1.00 | METAP2 (0.62) | METAP2METAP1REN | |
| SCHEMBL2010726 | 0.91 | METAP2 (0.51) | METAP2METAP1REN | |
| SCHEMBL7341595 | 0.85 | METAP2 (0.60) | METAP2METAP1REN | |
| SCHEMBL6475764 | 0.85 | METAP2 (0.60) | METAP2METAP1REN | |
| SCHEMBL6477560 | 0.85 | METAP2 (0.59) | METAP2METAP1REN | |
| SCHEMBL6477996 | 0.85 | METAP2 (0.59) | METAP2METAP1REN | |
| SCHEMBL6478513 | 0.85 | METAP2 (0.59) | METAP2METAP1REN | |
| SCHEMBL6477548 | 0.83 | METAP2 (0.61) | METAP2METAP1REN | |
| SCHEMBL7352599 | 0.82 | METAP2 (0.64) | METAP2METAP1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266950-B1 | Nor-statine and nor-cyclostatine polypeptides | PFIZER (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |