Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10681278 | 0.98 | STAT3 (0.58) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL11709672 | 0.90 | STAT3 (0.56) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL10854182 | 0.82 | MAPT (0.56) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL8115720 | 0.82 | STAT3 (0.59) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL10850355 | 0.79 | STAT3 (0.53) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL14418732 | 0.79 | STAT3 (0.58) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL9516163 | 0.78 | HTR2A (0.58) | HTR1DHTR1BHTR2AHTR2CHTR7 | |
| SCHEMBL10851503 | 0.78 | STAT3 (0.51) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL2364045 | 0.78 | STAT3 (0.57) | STAT3HSD17B10GFERPOLBMEN1 | |
| SCHEMBL30897295 | 0.78 | STAT3 (0.58) | STAT3HSD17B10GFERPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227488-A | AZA SPIRO DECANE AND USE THEREOF IN TREATING CNS DISORDERS | NOVO NORDISK A/S (DK) | 1993-07-13 | — | — | US | disclosed |
| EP-0495826-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-07-29 | — | — | EP | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |
| US-4725604-A | ADMINISTERING 2-(SUBSTITUTED-ETHYLTHIO) INDOLES OR BENZOTHIOPHENES | MCNEILAB, INC. (US) | 1988-02-16 | — | — | US | disclosed |
| US-4584302-A | ADMINISTERING INDOLE AND BENZOTHIPOPHENE COMPOUNDS HAVING PENDANT PYRROLIDINYLIDENE AMINO OR PIPERIDINYIDENEAMINO GROUPS | MCNEILAB, INC. (US) | 1986-04-22 | — | — | US | disclosed |
| US-4059583-A | CARDIAC RATE LOWERING | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-11-22 | — | — | US | disclosed |