Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517516 | 0.86 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL9847609 | 0.84 | CHRM1 (0.57) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9029298 | 0.78 | CHRM1 (0.72) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9030861 | 0.78 | CHRM1 (0.55) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9779405 | 0.77 | CHRM1 (0.50) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9030132 | 0.76 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL968737 | 0.74 | — | — | |
| SCHEMBL15473370 | 0.74 | MCHR1 (0.38) | KMT2AALDH1A1 | |
| SCHEMBL7748360 | 0.73 | — | — | |
| SCHEMBL21680745 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411615-B1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER LAMBERT CO (US) | 1993-12-29 | — | — | EP | claimed |
| EP-0411615-A1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER-LAMBERT COMPANY (US) | 1991-02-06 | — | — | EP | claimed |
| EP-0411615-B1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER LAMBERT CO (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0411615-A1 | 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | WARNER-LAMBERT COMPANY (US) | 1991-02-06 | — | — | EP | disclosed |
| US-4988688-A | Cognitive activators | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | disclosed |