Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515054 | 1.00 | EPHX1 (0.41) | EPHX1GAAMAPTALOX12ATM | |
| SCHEMBL9514242 | 0.94 | GAA (0.41) | EPHX1GAAMAPTALOX12ATM | |
| SCHEMBL9514236 | 0.94 | GAA (0.41) | EPHX1GAAMAPTALOX12ATM | |
| SCHEMBL9515045 | 0.86 | GAA (0.38) | GAAMAPTSMN1; SMN2ALDH1A1XPO1 | |
| SCHEMBL9515051 | 0.86 | GAA (0.38) | GAAMAPTSMN1; SMN2ALDH1A1XPO1 | |
| SCHEMBL9511451 | 0.80 | SMN1; SMN2 (0.43) | GAAMAPTALOX12ATMSMN1; SMN2 | |
| SCHEMBL21399776 | 0.79 | EPHX1 (0.49) | EPHX1GAAMAPTALOX12ATM | |
| SCHEMBL21382300 | 0.79 | EPHX1 (0.53) | EPHX1GAAMAPTALOX12ATM | |
| SCHEMBL9512935 | 0.77 | GAA (0.43) | GAAMAPTHPGDALDH1A1 | |
| SCHEMBL9512946 | 0.77 | GAA (0.43) | GAAMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212340-B1 | 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparations and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-10-27 | — | — | EP | disclosed |
| US-4839348-A | HYPOTENSIVE AGENTS; ANTICOAGULANTS, ANTIISCHEMIC AGENTS | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-06-13 | — | — | US | disclosed |
| EP-0212340-A1 | 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparations and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-04 | — | — | EP | disclosed |