Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9512935 | 1.00 | GAA (0.43) | GAAGLO1LMNAKMT2AALDH1A1 | |
| SCHEMBL9515051 | 0.79 | GAA (0.38) | GAAKMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL9515045 | 0.79 | GAA (0.38) | GAAKMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL9515044 | 0.77 | EPHX1 (0.41) | GAAALDH1A1MAPTHPGD | |
| SCHEMBL11264404 | 0.76 | ALDH1A1 (0.45) | GAAGLO1LMNAKMT2AALDH1A1 | |
| SCHEMBL11256199 | 0.75 | GAA (0.47) | GAAGLO1LMNAKMT2AALDH1A1 | |
| SCHEMBL11385493 | 0.75 | GAA (0.47) | GAAGLO1LMNAKMT2AALDH1A1 | |
| SCHEMBL11257484 | 0.74 | ALDH1A1 (0.45) | GAAGLO1LMNAKMT2AALDH1A1 | |
| SCHEMBL11267322 | 0.73 | SMN1; SMN2 (0.43) | LMNAKMT2AALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13916496 | 0.71 | CYP2C19 (0.52) | GAALMNAKMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212340-B1 | 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparations and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-10-27 | — | — | EP | disclosed |
| US-4839348-A | HYPOTENSIVE AGENTS; ANTICOAGULANTS, ANTIISCHEMIC AGENTS | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-06-13 | — | — | US | disclosed |
| EP-0212340-A1 | 2-(heteroalkyl)-1,4-dihydropyridines, process for their preparations and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-04 | — | — | EP | disclosed |