Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 14/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 14/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513652 | 0.92 | LTB4R (0.43) | LTB4RLTB4R2PPARDPPARGPPARA | |
| SCHEMBL9514454 | 0.92 | LTB4R (0.43) | LTB4RLTB4R2PPARDPPARGPPARA | |
| SCHEMBL9515385 | 0.89 | LTB4R (0.41) | LTB4RLTB4R2PPARDPPARGPPARA | |
| SCHEMBL9513132 | 0.88 | LTB4R (0.51) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9513714 | 0.88 | LTB4R (0.51) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9515370 | 0.88 | LTB4R (0.51) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9513208 | 0.88 | LTB4R (0.43) | LTB4RLTB4R2PPARDPPARGPPARA | |
| SCHEMBL9515326 | 0.88 | LTB4R (0.43) | LTB4RLTB4R2PPARDPPARGPPARA | |
| SCHEMBL9512244 | 0.86 | LTB4R (0.53) | LTB4RLTB4R2PPARDPPARGPPARA | |
| SCHEMBL9512237 | 0.84 | LTB4R (0.47) | LTB4RLTB4R2PPARDPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342664-B1 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | SEARLE & CO (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5093353-A | 2,2-di-substituted benzopyran leukotriene-D4 antagonists | G. D. SEARLE & CO. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |