Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515497 | 1.00 | PPARA (0.46) | PPARAEGFRBCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL9515816 | 1.00 | PPARA (0.46) | PPARAEGFRBCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL9517205 | 1.00 | PPARA (0.46) | PPARAEGFRBCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL9515824 | 0.99 | PPARA (0.46) | PPARAEGFRBCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL9516911 | 0.92 | MAPT (0.47) | BCL2L1MCL1SMN1; SMN2GAANPC1 | |
| SCHEMBL9515521 | 0.92 | MAPT (0.47) | BCL2L1MCL1SMN1; SMN2GAANPC1 | |
| SCHEMBL9515737 | 0.92 | NPC1 (0.49) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL9519339 | 0.92 | NPC1 (0.49) | SMN1; SMN2NPC1MAPTRAB9AMEN1 | |
| SCHEMBL9517289 | 0.92 | MAPT (0.47) | BCL2L1MCL1SMN1; SMN2GAANPC1 | |
| SCHEMBL9515740 | 0.92 | RAB9A (0.48) | PPARABCL2L1MCL1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |