Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 4/20 | 0.53 |
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 5/20 | 0.52 |
| ▸ | CTSH | P09668 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norvaline SCHEMBL9515720 | 0.92 | POLB (0.61) | POLBGFERCTSLCTSBCYP3A4 | |
| Norvaline SCHEMBL9514591 | 0.92 | POLB (0.58) | POLBGFERCTSLCTSBCYP3A4 | |
| SCHEMBL9514870 | 0.88 | POLB (0.56) | POLBGFERCTSLCTSBCYP3A4 | |
| SCHEMBL7268468 | 0.84 | POLB (0.76) | POLBGFERCTSLCTSBCYP3A4 | |
| SCHEMBL7268474 | 0.84 | POLB (0.76) | POLBGFERCTSLCTSBCYP3A4 | |
| SCHEMBL7275964 | 0.84 | POLB (0.74) | POLBGFERCTSLCTSBCYP3A4 | |
| SCHEMBL5193787 | 0.84 | POLB (0.74) | POLBGFERCTSLCTSBCYP3A4 | |
| SCHEMBL9514522 | 0.82 | POLB (0.58) | POLBGFERCTSLCTSBCYP3A4 | |
| Leucine SCHEMBL1406330 | 0.82 | CTSS (0.62) | POLBGFERCTSLCTSBGAA | |
| SCHEMBL7607635 | 0.81 | POLB (0.66) | POLBGFERCTSLCTSBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266950-B1 | Nor-statine and nor-cyclostatine polypeptides | PFIZER (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |