Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517158 | 0.97 | NPC1 (0.46) | HSP90AA1P4HTMMLYCDBCL2L1MCL1 | |
| SCHEMBL9515987 | 0.94 | NPC1 (0.49) | P4HTMBCL2L1MCL1NPC1RAB9A | |
| SCHEMBL9519274 | 0.88 | SCN3A (0.51) | P4HTMBCL2L1MCL1EPHX2KDM4E | |
| SCHEMBL9517097 | 0.87 | HSP90AA1 (0.51) | HSP90AA1P4HTMMLYCDPTAFRNPC1 | |
| SCHEMBL9517241 | 0.84 | P4HTM (0.61) | P4HTMBCL2L1MCL1 | |
| SCHEMBL9517800 | 0.84 | NPC1 (0.52) | HSP90AA1P4HTMMLYCDNPC1RAB9A | |
| SCHEMBL9143189 | 0.84 | P4HTM (0.52) | HSP90AA1P4HTMMLYCDBCL2L1MCL1 | |
| SCHEMBL9517102 | 0.83 | NPC1 (0.49) | P4HTMBCL2L1MCL1NPC1RAB9A | |
| SCHEMBL9138472 | 0.83 | P4HTM (0.53) | HSP90AA1P4HTMMLYCDPTAFRNPC1 | |
| SCHEMBL9018032 | 0.82 | HSP90AA1 (0.46) | HSP90AA1P4HTMMLYCDBCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |